KMID : 1197720110040020055
|
|
´ëÇÑÆÄŲ½¼º´ ¹× ÀÌ»ó¿îµ¿Áúȯ ÇÐȸÁö 2011 Volume.4 No. 2 p.55 ~ p.59
|
|
MicroRNAs in Experimental Models of Movement Disorders
|
|
Lee Soon-Tae
Kim Man-Ho
|
|
Abstract
|
|
|
MicroRNAs (miRNAs) are small RNAs comprised of 20?25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as oncology, immunology, and cardiovascular diseases. In Parkinson¡¯s disease and related disorders, multiple studies have identified the implications of specific miRNAs and the polymorphisms of miRNA target genes during the disease pathogenesis. With a focus on Parkinson¡¯s disease, spinocerebellar ataxia, hereditary spastic paraplegia, and Huntington¡¯s disease, this review summarizes and interprets the observations, and proposes future research topics in this field.
|
|
KEYWORD
|
|
MicroRNA, Parkinson¡¯s disease, Spinocerebellar ataxia, Hereditary spastic paraplegia, Huntington¡¯s disease
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|